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That May Help with
Alcoholism
Folate deficiency occurs in a number of situations. For example, low dietary intake and diminished absorption, as in alcoholism, can result in a decreased supply of folate.
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Niacin
Alcoholism is the prime cause of Vitamin B3 (Niacin) deficiency.
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Methionine’s activity in the liver and against alcoholism and withdrawal symptoms add to the list of detoxification benefits provided by the amino acid.
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Evening Primrose Oil
Evening Primrose Oil may help lessen cravings for alcohol and prevent liver damage. Some of this information comes from animal studies
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Enzyme May Offer New Target for Treatment of Alcoholism
| (Mood & Behavior Support) By Kurt Ullman WebMD Medical News |
|
Oct. 18, 1999 (Indianapolis) -
Researchers from the University of California, San Francisco, have identified an enzyme that might one day become useful in the treatment of alcoholism. Their report, published in Nature Neuroscience, shows that mice genetically engineered to lack the enzyme PKC epsilon were 75% less likely to drink alcohol in a self-administered test than were mice with the enzyme.
"Studies have shown that the brain chemical GABA is involved in the rewarding properties of alcohol," says Clyde Hodge, PhD, from the Ernest Gallo Research Center at UCSF. There are receptors on brain cells that use GABA as the way to signal the brain to feel relaxed, gratified, or sedated. Alcohol and a group of drugs known as benzodiazepines, such as Valium, Xanax, and Ativan, work with GABA to make the signals stronger and last longer.
The researchers found that in the mice without the enzyme, the GABA receptors were more sensitive to alcohol. That heightened sensitivity actually decreased the craving for alcohol. Hodge tells WebMD, "We first wanted to know if the mice would self-administer less alcohol if the PKC epsilon enzyme was missing and then try and find out why it occurred."
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Helps Liver Recover from Excessive Alcohol
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| By Becky McCall |
Taurine has long been used in household goods, but has shot to prominence as the ingredient that adds kick to energy drinks such as Red Bull or Lipovitan. It is also found naturally at lower levels in seafood and is manufactured by our bodies.
The safety of this colourless, crystalline substance in combination with caffeine - as it is in energy drinks - has been the subject of much controversy. After the launch of Red Bull, there were reports that three people in Sweden died after drinking it, although a definitive link has not been proven.
Erring on the side of caution, the Swedish National Food Administration issued a warning advising consumers to avoid drinking it with alcohol or after heavy exercise. France banned it, Norway classified it as a medicine and for a long time it was only available in pharmacies in Japan.
But scientists studying the effects of taurine on liver toxicity beg to differ. Researchers at the University of London's School of Pharmacy say taurine can reverse the liver damage caused by alcoholism or even a heavy night's drinking.
Damage limitation
When we drink to excess, fat builds up in the liver, causing it to swell and reducing blood flow to this organ so vital in breaking down the toxins alcohol. Even one night's over-indulgence can cause fat to accumulate.
"It plays a role in digestion and the nervous system, amongst other things, and has been used to treat heart failure and diabetes. We make it naturally but cats would be severely ill without it in their diets because they cannot manufacture it themselves," he says.
To see whether it could also protect the liver, his team gave rats alcohol and taurine for a month, and found that it prevented fat build-up in the liver. Even more surprisingly, when given to rats after they had drunk alcohol, taurine continued to reverse the liver damage.
"According to our study findings, it is possible that adding taurine to alcohol during drinking could help to minimise liver damage and ward off a hangover, although we need to carry out further studies to confirm the effect in humans," he says.
Scientists in Ireland found a similar effect in children suffering from fatty liver due to obesity.
The next step researchers hope to take is to trial taurine in the many livers discarded because they are too damaged for donation - but there is resistance from funding authorities who feel that such work may encourage irresponsible alcohol consumption.
Good cheer
The hope is that taurine might eventually be used to treat alcohol-related problems. Professor Chris Day, specialist in liver medicine at the University of Newcastle upon Tyne, often treats fatty liver patients. The condition is increasingly common due to binge drinking and to the rise in obesity - he estimates it affects about one-fifth of the population.
Short of advising patients to abstain from alcohol and lose weight, there is little else that a doctor can do to treat fatty liver. Taurine would be the first treatment of its kind, if proven to be effective in humans. In fact, the trial on obese children found taurine to be effective in treating fatty liver irrespective of whether the children lost weight.
The results are encouraging for those keen to minimise the harm the festive season inflicts. And when it comes to damage limitation, perhaps a taurine-rich energy drink might be just the thing with which to toast the New Year.
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Milk Thistle
University of Maryland Medical Center Report:
Liver disease from alcohol A comprehensive review by the U.S. Agency for Healthcare Research and Quality (AHRQ) recently identified 16 scientific studies on the use of milk thistle for the treatment of various forms of liver disease. A European standardized extract of milk thistle was used in most of the trials.
Problems in study design (such as small numbers of participants, variations in the causes of liver disease, and differences in dosing and duration of milk thistle therapy) made it difficult to draw any definitive conclusions. However, five of seven studies evaluating milk thistle for alcoholic liver disease found significant improvements in liver function. Those with the mildest form of the disease appeared to improve the most. Milk thistle was less effective for those with severe liver disease such as cirrhosis. Cirrhosis is characterized by scarring and permanent, non-reversible damage to the liver. It is often referred to as end-stage liver disease.
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The statements & claims found on this website have not been
evaluated by the Food & Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
© Copyright 2006, 2007, by Good Health Group of America, LLC.
311 Bainbridge Street, Philadelphia PA USA 19147.
www.GoodHealthCo.com
___________________________________________________________________________
The statements & claims found on this website have not been evaluated by the Food & Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
© Copyright 2006, 2007, by Good Health Group of America, LLC.
311 Bainbridge Street, Philadelphia PA USA 19147.
www.GoodHealthCo.com
