Price range: 1-2 containers: $21.95 each.  3-5: $20.95.   6+: $19.95

Glucose Control is designed to suppress the appetite and to aid the body in processing glucose, a sugar which the body can use to store fat.

Glucose Control contains the herb garcinia cambogia, or gambooge, a nutrient which helps to inhibit the conversion of glucose into fat.  Chromium is also added to help in the burning of fat.


The other components in this formula are herbal supplements traditionally used to aid the body’s natural digestive processes and to curb appetite. 

These ingredients include Guarana (Seed), Kola Nut (Roasted Seed), Eleutherococcus senticosus (Root), Wood Betony (Entire Plant), Beet Powder (Root), Cayenne (Fruit), American Centaury (Entire Plant), Gotu Kola (Entire Plant), Ho Shou Wu (Entire Plant), and Green Tea Extract.

(See complete listing of ingredients.)

BACKGROUND:

Hydroxycitric acid, the main healthy constituent of the gambooge plant, also prevents the body from converting much of this remaining glucose to fat.  When combined with a healthy dosage of chromium, these two substances increase the efficiency with which the body uses glucose, with the result that less glucose is converted into fat and more is used for energy. 


OTHER INGREDIENTS:
           
In June of 2001, the Journal of Human Nutrition and Dietetics published a study in which patients treated with guarana lost almost ten times as much weight as the patients who were not given guarana.

In many west African cultures, kola nut is chewed to prevent hunger pangs.  Kola nut was the original ingredient in cola soft drinks, but is no longer used for that purpose.  While chewing the nut itself can cause stained teeth with prolonged use, ingesting kola nut in supplement form avoids that risk.

The remaining ingredients in this formula are laxatives and digestive support substances.   Combined with a moderate, healthy diet, Glucose Control supplements are a means of assisting the body in efficiently processing glucose and thereby reducing the storage of fat.

 

View Related Products

 

 

Return to Top of Page

Studies:

GARCINIA CAMBOGIA:
“High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. “
Saito,-M; Ueno,-M; Ogino,-S; Kubo,-K; Nagata,-J; Takeuchi,-M
Food-Chem-Toxicol. 2005 Mar; 43(3): 411-9

We investigated the ability of Garcinia cambogia extract containing (-)-hydroxycitric acid (HCA) to suppress body fat accumulation in developing male Zucker obese (fa/fa) rats. We also examined histopathologically the safety of its high doses. Diets containing different levels of HCA (0, 10, 51, 102 and 154 mmol/kg diet) were fed to 6-week-old rats for 92 or 93 days. Each diet group was pair-fed to the 154 mmol HCA/kg diet group. Epididymal fat accumulation and histopathological changes in tissues were observed. The highest dose of HCA-containing Garcinia cambogia (154 mmol HCA/kg diet) showed significant suppression of epididymal fat accumulation in developing male Zucker obese rats, compared with the other groups. However, the diets containing 102 mmol HCA/kg diet and higher (778 and 1244 mg HCA/kg BW/d, respectively) caused potent testicular atrophy and toxicity, whereas diets containing 51 mmol HCA/kg diet (389 mg HCA/kg BW/d) or less did not. Accordingly, 51 mmol HCA/kg diet (389 mg HCA/kg BW/d) was deemed to be the no observed adverse effect level (NOAEL).

“Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control.”
Preuss,-H-G; Garis,-R-I; Bramble,-J-D; Bagchi,-D; Bagchi,-M; Rao,-C-V; Satyanarayana,-S
Int-J-Clin-Pharmacol-Res. 2005; 25(3): 133-44


The weight-loss efficacy of a novel, water-soluble, calcium-potassium salt of (-)-hydroxycitric acid (HCA-SX) was re-examined in 90 obese subjects (BMI: 30-50.8 kg/m2). We combined data from two previously reported randomized, double-blind, placebo-controlled clinical studies in order to achieve a better statistical evaluation based on a larger population. This re-examination of data also allowed us to reflect more intensely on various aspects of weight loss studies. Subjects were randomly divided into three groups: group A received a daily dose of HCA-SX 4, 667 mg (providing 2,800 mg HCA per day); group B was given a daily dose of a combination of HCA-SX 4,667 mg, niacin-bound chromium (NBC) 4 mg (providing 400 microg elemental chromium), and Gymnema sylvestre extract (GSE) 400 mg (providing 100 mg gymnemic acid); and group C received a placebo in three equally divided doses 30-60 min before each meal. All subjects were provided a 2,000 kcal diet/day and participated in a supervised walking program for 30 min/day, 5 days/week.

Eighty-two subjects completed the study. At the end of 8 weeks, in group A, both body weight and BMI decreased by 5.4%, low-density lipoprotein and triglycerides levels were reduced by 12.9% and 6.9%, respectively, while high-density lipoprotein levels increased by 8.9%, serum leptin levels decreased by 38%, serotonin levels increased by 44.5% and urinary excretion of fat metabolites increased by 32-109%. Group B demonstrated similar beneficial changes, but generally to a greater extent. No significant adverse effects were observed. The combined results confirm that HCA-SX and, to a greater degree, the combination of HCA-SX plus NBC and GSE reduce body weight and BMI, suppress appetite, improve blood lipid profiles, increase serum leptin and serotonin levels and increase fat oxidation more than placebo. We conclude that dosage levels, timing of administration, subject compliance and bioavailability of HCA-SX significantly affect results and that when taken as directed, HCA-SX is a highly effective adjunct to healthy weight control.

“Evaluation of in vitro effects of natural substances of plant origin using a model of protein glycoxidation.”
Bousova,-I; Martin,-J; Jahodar,-L; Dusek,-J; Palicka,-V; Drsata,-J
J-Pharm-Biomed-Anal. 2005 Apr 29; 37(5): 957-62
In an in vitro model with purified porcine aspartate aminotransferase (AST, EC 2.6.1.1) as the protein, the effects of phenolic antioxidants of plant origin (arbutin, methylarbutin, ferulic and isoferulic acids, o-coumaric and p-coumaric acids, quinic acid), flavonoids (baicalin and baicalein), and of hydroxycitric acid (HCA) at 0.5-50 mM concentration on the enzyme activities and on its glycation by 50 mM D-fructose as the glycating agent were studied. During incubation with AST at 37 degrees C up to 24 days, fructose alone decreased AST activities as a result of protein glycation. In the absence of fructose, 50 mM phenolic compounds gradually decreased AST activity, while no or a weak effect of individual compounds was found at 3 mM concentration. A direct negative effect on AST was pronounced with ferulic acid. On the other hand, beneficial influences of phenolic compounds on glycation of AST by fructose were found mostly at 3 mM concentration. Effects on glycation were vague at 50 mM concentration, probably due to a combination of direct negative influences and antiglycation effects of individual compounds. No effect, neither positive nor negative, on AST activity and protein glycation, was found with quinic acid. The flavonoid baicalin and its aglycon baicalein rapidly decreased the in vitro activity of the enzyme in all concentrations used (0.5-3 mM), and no beneficial effects of the compounds on glycation of the enzyme by fructose were found. The influence of HCA on glycation was concentration-depended, ranging from beneficial inhibition of glycation at 2.5 mM concentration to a strong decrease in AST activity at 10 mM HCA. Both the beneficial and undesirable effects of natural antioxidants should be considered in case they are used as antiglycation factors. The results obtained can contribute to the evaluation of quality of various generally recommended antioxidants.

“Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement.”
Roy,-S; Rink,-C; Khanna,-S; Phillips,-C; Bagchi,-D; Bagchi,-M; Sen,-C-K
Gene-Expr. 2004; 11(5-6): 251-62
Obesity is a global public health problem, with about 315 million people worldwide estimated to fall into the WHO-defined obesity categories. Traditional herbal medicines may have some potential in managing obesity. Botanical dietary supplements often contain complex mixtures of phytochemicals that have additive or synergistic interactions. The dried fruit rind of Garcinia cambogia, also known as Malabar tamarind, is a unique source of (-)-hydroxycitric acid (HCA), which exhibits a distinct sour taste and has been safely used for centuries in Southeastern Asia to make meals more filling. Recently it has been demonstrated that HCA-SX or Super Citrimax, a novel derivative of HCA, is safe when taken orally and that HCA-SX is bioavailable in the human plasma as studied by GC-MS. Although HCA-SX has been observed to be conditionally effective in weight management in experimental animals as well as in humans, its mechanism of action remains to be understood.

We sought to determine the effects of low-dose oral HCA-SX on the body weight and abdominal fat gene expression profile of Sprague-Dawley rats. We observed that at doses relevant for human consumption dietary HCA-SX significantly contained body weight growth. This response was associated with lowered abdominal fat leptin expression while plasma leptin levels remained unaffected. Repeated high-density microarray analysis of 9960 genes and ESTs present in the fat tissue identified a small set (approximately 1% of all genes screened) of specific genes sensitive to dietary HCA-SX. Other genes, including vital genes transcribing for mitochondrial/nuclear proteins and which are necessary for fundamental support of the tissue, were not affected by HCA-SX. Under the current experimental conditions, HCA-SX proved to be effective in restricting body weight gain in adult rats. Functional characterization of HCA-SX-sensitive genes revealed that upregulation of genes encoding serotonin receptors represent a distinct effect of dietary HCA-SX supplementation.

“Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss.”
Preuss,-H-G; Bagchi,-D; Bagchi,-M; Rao,-C-V; Dey,-D-K; Satyanarayana,-S
Diabetes-Obes-Metab. 2004 May; 6(3): 171-80
AIM: The efficacy of optimal doses of highly bioavailable (-)-hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. HCA-SX has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has demonstrated its ability to maintain healthy insulin levels, while GSE has been shown to regulate weight loss and blood sugar levels. METHODS: A randomized, double-blind, placebo-controlled human study was conducted in Elluru, India for 8 weeks in 60 moderately obese subjects (ages 21-50, BMI greater than26 kg/m(2)).

Subjects were randomly divided into three groups. Group A was administered HCA-SX 4667 mg, group B was administered a combination of HCA-SX 4667 mg, NBC 4 mg and GSE 400 mg, while group C was given placebo daily in three equally divided doses 30-60 min before meals. All subjects received a 2000 kcal diet/day and participated in supervised walking. RESULTS: At the end of 8 weeks, body weight and BMI decreased by 5-6% in both groups A and B. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced in both groups, while high-density lipoprotein levels and excretion of urinary fat metabolites increased in both groups. A marginal or non-significant effect was observed in all parameters in group C. CONCLUSION: The present study shows that optimal doses of HCA-SX and, to a greater degree, the combination of HCA-SX, NBC and GSE can serve as an effective and safe weight-loss formula that can facilitate a reduction in excess body weight and BMI, while promoting healthy blood lipid levels.

RETURN TO TOP

CHROMIUM:

Study Finds Chromium Supports Weight Management
In a study conducted at the Health and Medical Research Foundation in San Antonio, Texas, researchers examined the effect of chromium picolinate on body composition in 154 subjects*. The randomized, double-masked, placebo-controlled study administered 200 and 400mcg of chromium daily for a total of 72 days. Body composition was measured before and after the test period by using underwater displacement testing. Patients however were allowed to follow any diet they chose, and did not receive any weight loss, dietary or exercise guidance from the researchers. On completion of the post trial exam, body composition improvement (BCI) was calculated for each subject by adding the amount of body fat lost and nonfat mass gained, while then subtracting fat gained and lean mass lost. The researchers found that both the 200mcg and 400mcg groups had significantly higher positive changes in BCIs compared to placebo.

Chromium Review by Physicians’ Select:

Chromium chelate - is an essential trace mineral that is required for proper glucose and fat metabolism. Chromium can be found in unsaturated fats, clams, meats, brewer's yeast, liver, whole grain, cereal, shellfish, etc.

PHYSIOLOGY:
Chromium is required for normal protein, fat, and carbohydrate metabolism. Chromium plays a role in regulating appetite, reducing the cravings for sugar and increasing lean body mass.
Chromium contains a special bioactive formulation called Glucose Tolerance Factor (GTF).

GTF facilitates insulin action by binding insulin to cell membranes, serving as a bridge between the insulin molecule and the cell membrane receptor sites. Remember, glucose is used by cells for energy, insulin is used by by the body to transport the glucose into the cells, Chromium's GTF factor essentially assist the glucose to enter the cell. Therefore, all both insulin and GTF are needed for proper glucose metabolism. Chromium deficiency can lead to Type II diabetes and heart disease. Chromium deficiency is thought to contribute to glucose intolerance.

Chromium has also been shown to reduce levels of harmful LDL cholesterol (a form of cholesterol that has been linked to heart disease) and increase beneficial HDL cholesterol (HDL cholesterol helps return cholesterol to the liver, keeping it from building up in the blood vessels).

CLINICAL STUDIES:
Aside from the clinical studies concerning the importance of Chromium's GTF factor in the regulation of glucose. Chromium also promotes a positive effect on physical performance while decreasing overall body fat of athletes in training. Lefavi RG, Anderson RA, Keith RE, Wilson GD, McMillan JL, Stone MH. Efficacy of chromium in athletes: emphasis on anabolism. Int. J. Sports Nutr. 1992; 2: 111 – 122.

MODERN DAY USES:
Today, Chromium is prescribed by physicians and herbal specialist for the following positive benefits:
•          Appetite suppressant
•          Lowers blood sugar
•          Increases insulin sensitivity
•          Decreases body fat /increases lean body mass
•          Helps maintain health blood lipid levels, specifically triglycerides and HDL cholesterol

PRECAUTIONS AND/OR ADVERSE EFFECTS:
Individuals with preexisting medical conditions should consult with their physician particularly if they are taking prescription or over-the-counter-medications or supplements. Women who are pregnant or breast feeding and children should also consult with their physician prior to taking any new supplements. Chromium chelate did not have any reported significant side effects or medication interactions at the time of this writing.

ALL ABOUT THE USES FOR CHROMIUM AND CHROMIUM SUPPLEMENTS
Chromium is an essential trace mineral that comes in several different varieties –- most commonly as polynicotinate or picolinate. It is estimated that 90% of people in North America are deficient in this crucial mineral; combined with the fact that the uses for chromium (and benefits) are very broad, it is not surprising that they are now currently among the top three best selling supplements in the U.S.

USES FOR CHROMIUM: CHROMIUM SUPPLEMENTS
Chromium supplements have been praised as being everything from aiding in weight loss, to a mineral capable of enhancing the health of diabetics, having an ability to build lean muscle, and improving heart health by lowering bad cholesterol (LDL) and raising good cholesterol (HDL).

To understand these uses for chromium, let’s briefly look at the varied ways this mineral works in the body.

First, chromium plays an essential role in breaking down carbohydrates, proteins, and fats.

Because fats are believed to be one cause of high cholesterol, this breakdown may help protect against heart disease.

Second, chromium may help insulin regulate blood sugar levels (glucose). Some people (diabetics, for example) are often insulin resistant. What this means, simply, is that the body has a tough time dealing with blood sugar. The pancreas has the job of producing more insulin to help bring down elevated blood sugar levels, which, in turn, taxes this organ by making it work more strenuously.

Eventually, diabetes can develop, as a point will be reached where the pancreas cannot manufacture enough insulin. Chromium supplements, therefore, may help those who are insulin resistant by keeping elevated glucose levels in check before it stresses the pancreas.

In addition, because glucose is the body’s primary source of fuel, what is not used by the body is stored as fat. Therefore, this may explain why studies have shown one of the most prominent uses for chromium is aiding in weight loss.

It is important to realize that the typical Western diet is high in saturated fats, sugars, flours, and processed and refined foods, which creates high levels of blood sugar (glucose) in the body. Therefore, the first goal is not to just reach for chromium supplements, however much they may help, but to reduce these types of foods in your diet.

All in all, however, as one can see, there are many uses for chromium by the human body.

NUTRITIONAL-SUPPLEMENT-INFO’S OPINION ON THE USES FOR CHROMIUM
We believe that there is strong evidence chromium is a supplement with a wide range of benefits. In some areas, the evidence is stronger, such as its role in insulin function, and much more speculative in others, such as its role in helping to produce more lean muscle.
Because it is such a popular supplement, we are hopeful that future studies will help clarify which of its alleged benefits can actually be attributed to it.

 

From NutraSanus…
Chromium is a trace element that has been shown to play a role in the body's processing of different food items. A trace element is a substance that is required by the body in very small amounts for proper growth and functioning. Individuals with likelihood of low chromium levels include: elderly persons, individuals with extremely poor diets or diets very high in refined sugars, pregnant or breast-feeding women, individuals under chronically stressful conditions, and those who depend on total parental nutrition (feeding through an intravenous line).

Exercise and increasing age may also reduce body stores of chromium.
For people that suffer from high blood sugar, chromium appears to help the body better utilize insulin and increase the number of insulin receptors in the body. Consequently, it is believed that chromium may be helpful when used in connection with diabetes, especially type II diabetes.

Chromium may be beneficial for individuals with certain types of high cholesterol because chromium can alter the breakdown of fats in the diet. Additionally, chromium has been publicized as a weight loss agent and athletic supplement for increasing lean body mass. However, studies concerning these effects of chromium are not entirely conclusive.

RETURN TO TOP

GUARANA:

“Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males.”
Sale,-C; Harris,-RC; Delves,-S; Corbett,-J
International-journal-of-obesity-and-related-metabolic-disorders:-journal-of-the-International-Association-for-the-Study-of-Obesity. 2006 May; 30(5): 764-773.

Objective: This study examined the acute effects of ingesting a widely used commercial formula containing extracts of bitter orange, green tea and guarana (Gx) on the metabolic rate and substrate utilisation in overweight, adult males at rest (study 1) and during treadmill walking (study 2). Subjects: Two different groups of 10 sedentary males with more than 20% body fat participated in studies 1 and 2. Design: In each study, subjects participated in two experimental trials during which they were given two 500 mg capsules containing either Gx or a placebo (P) in a counterbalanced double-blind manner. Doses of the main active ingredients were 6 mg of synephrine, 150 mg caffeine and 150 mg catechin polyphenols. Measurements: In study 1, subjects completed 7 h supine rest with baseline measures taken during the first hour, with expired gases, blood pressure, heart rate and venous blood being collected every 30 min for the remaining 6 h following ingestion of Gx or P. In study 2, subjects exercised for 60 min at 60% heart rate reserve following ingestion of Gx or P 1 h previously. Venous blood samples were collected twice at rest and at 5, 10, 15, 20, 30, 40, 50 and 60 min, with expired gas measurements taken at 4, 9, 14, 19, 29, 39, 49 and 59 min. In both studies, venous blood was analysed for NEFA, glycerol, glucose and lactate concentrations, while expired gases were used to calculate ATP production from carbohydrate and NEFA, as well as the total substrate utilised. Results and conclusion: The results did not show any significant effect of Gx ingestion on total ATP utilisation during 6 h rest or during 60 min treadmill walking. Changes were observed in the relative contributions of CHO and NEFA oxidation to ATP production in both studies, such that there was an increase in ATP production from CHO and a decrease from NEFA. The increase in CHO oxidation was shown to be as high as 30% at rest.

RETURN TO TOP OF PAGE

 

RETURN TO HOME PAGE

 

 

 

 

 

 

 

 

glucose control prevents conversion of glucose to fat

weight management

Good Health Group of America
www.goodhealthco.com